Battle of the clotbusters.
نویسنده
چکیده
The moment of revelation-maybe even of truthcame at 8 51 on a Tuesday morning in the vast auditorium of the Georgia World Congress Centre in Atlanta. It was the second day of the 40th annual scientific session of the American College ofCardiology and Peter Sleight, professor of cardiovascular medicine at the University of Oxford, with his colleagues Rory Collins and Richard Peto, was reporting preliminary results from the largest clinical trial in medical history. Coordinated by Dr Rory Collins from Oxford, the data for the third international study of infarct survival (ISIS-3) came from investigators in nearly 1000 hospitals in Europe, North America, and Australasia who had treated over 46000 patients suffering an acute myocardial infarction with one of three randomly assigned fibrinolytic agents: streptokinase, anistreplase, or tissue plasminogen activator (tPA). When Peter Sleight summoned up the slide showing the survival rates he had to tell those at the back of the packed auditorium that they were looking not at one line but three. The survival rates achieved with the agents in this double blinded study were virtually identical (fig 1). He had no such problem with the slide showing the incidence of cerebral bleeds -significantly fewer could be seen to occur in patients given streptokinase than in those given the other two agents. The excess of haemorrhagic strokes with tissue plasmir was fou Inav argume the deb which t -has d as effec not on efficacy
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ورودعنوان ژورنال:
- BMJ
دوره 302 6787 شماره
صفحات -
تاریخ انتشار 1991